S-adenosyl-L-methionine (commonly called “SAM-e”) is a naturally-occurring chemical component present in all cells of the body, essential in more than 200 metabolic pathways. SAM-e has been approved as a prescription drug for depression in Germany, Italy, Spain, and Russia, and has been in use in Europe for over three decades. It is available without a prescription in the United States and some other countries.<\/p>\n
SAM-e appears to be an effective treatment for depression where it can be used alone or with antidepressants. Since its side effects are less than those of many antidepressants, SAM-e might be tolerated better by many people. It works more rapidly and does not cause weight gain, sexual dysfunction, sedation, or cognitive interference.<\/p>\n
Recent studies have shown promise for treatment of dementia. Experts have suggested that SAM-e may also help address ADHD.<\/p>\n
SAM-e has not been studied in children or in pregnant or breast-feeding women.<\/p>\n
Drug Interactions<\/strong><\/p>\n There are no known drug interactions with SAM-e.<\/p>\n SAM-e may help prevent other drugs from interacting with the liver.<\/p>\n