Locator tool for new postpartum depression treatment


ZULRESSO is a prescription medication approved to treat adults with postpartum depression (PPD). This medication is different from other antidepressants because it works with the brain’s GABA system.

It is the first and only treatment that’s FDA approved for PDD and it works quickly – within 2.5 days.

The treatment is an IV infusion that is provided at specific centers to monitor your sleepiness. If you’re interested, please click here to access a Locator Tool for ZULRESSO Treating Centers.

About the ZULRESSO Locator Tool

Visitors to the Locator Tool for ZULRESSO Treating Centers can enter their city, state or zip code and will receive contact information for the closest ZULRESSO Treating Centers within 300 miles of the location entered.  Due to COVID-19, federal, state and local guidance may evolve and could impact the healthcare settings’ ability to accept or treat patients. We will be updating the Locator Tool bi-weekly to ensure we display only the healthcare settings that have indicated they are currently open and treating patients with PPD.

Patients may have questions about the ZULRESSO infusion prior to treatment. A patient’s doctor and healthcare team should be their primary resources for any questions regarding treatment with ZULRESSO, including identifying a treatment center. In addition, Sage Central is a source for patient support resources and programs for women with PPD and their families. Sage Central is available to provide information and personalized support to patients navigating the treatment journey with ZULRESSO Monday-Friday from 8 a.m. ET – 8 p.m. ET, 844-4-SAGERX (844-472-4379).

Standard disclaimer

This SELECT IMPORTANT SAFETY INFORMATION does not include all of the potential side effects of ZULRESSO.

ZULRESSO can cause serious side effects, including:

  • Excessive sedation and sudden loss of consciousness. ZULRESSO may cause you to feel very sleepy (excessive sedation) or pass out (loss of consciousness). Your healthcare provider should check you for symptoms of excessive sleepiness every 2 hours while you are awake.
    • During your infusion, tell your healthcare provider right away if you feel like you cannot stay awake during the time you are normally awake or if you feel like you are going to pass out. Your healthcare provider may lower your dose or stop the infusion until symptoms go away
    • You must have a caregiver or family member with you to help care for your child(ren) during your infusion
  • Because of the risk of serious harm resulting from excessive sedation or sudden loss of consciousness, ZULRESSO is only available through a restricted program called the ZULRESSO REMS.

ZULRESSO can cause other serious side effects, including:

  • Increased risk of suicidal thoughts or actions. ZULRESSO and other antidepressant medicines may increase suicidal thoughts and actions in some people 24 years of age and younger. Pay close attention to and tell your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:
    • Attempts to commit suicide, thoughts about suicide or dying, new or worse depression, other unusual or sudden changes in behavior or mood
  • Keep all follow-up visits and call your healthcare provider between visits as needed, especially if you have concerns about symptoms.

The most common side effects of ZULRESSO include:

  • Sleepiness, dry mouth, passing out, flushing of the skin or face

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before receiving ZULRESSO, tell your healthcare provider about all your medical conditions including if you drink alcohol, have kidney problems, are pregnant or think you may be pregnant, or are breastfeeding or plan to breastfeed. It is not known if ZULRESSO will harm your unborn baby. If you become pregnant during treatment, talk with your healthcare provider about enrolling with the National Pregnancy Registry for Antidepressants at 1-844-405-6185.

While receiving ZULRESSO, avoid the following:

  • Driving a car or doing other dangerous activities after your ZULRESSO infusion until your feeling of sleepiness has completely gone away
  • Do not drink alcohol

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

ZULRESSO and some medicines may interact with each other and cause serious side effects.

Especially tell your healthcare provider if you take other antidepressants, opioids, or Central Nervous System (CNS) depressants (such as benzodiazepines).

Please read the patient Medication Guide, including information about serious side effects, in the full Prescribing Information.

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