Atypical Antidepressants


Atypical antidepressants are the “other” antidepressants that may be prescribed to you if you don’t respond to other categories of antidepressants.

The Mayo Clinic[1] explains that atypical antidepressants ease depression by impacting chemical messengers -neurotransmitters - used to communicate between brain cells. Since atypical antidepressants are drugs that don’t clearly fit into a single category, each one works differently and on different neurotransmitters.

Examples include (brand name italicized):

  • Bupropion (Wellbutrin, Forfivo, Aplenzin)
  • Mirtazapine (Remeron)
  • Nefazodone
  • Trazodone
  • Vortioxetine (Trintellix)

Side Effects[1]:

Each drug has its own side effects but most atypical antidepressants include the following:

  • Dry mouth
  • Drowsiness
  • Lightheadedness

[1] Mayo Clinic Staff. “Atypical Antidepressants.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 25 June 2016,

Treatment & Resources